The opioid epidemic is well-established and the number of opioid overdose deaths continue to grow. Other substances are causing significant concern in the Houston area with half of psychiatric patients suffering from an addiction that may be aggravating their primary symptoms. This symposium will provide information about recent advances and practical guidance on co-occurring psychiatric and substance use disorders. Researchers will present on the impact of synthetic cannabinoids and electronic cigarettes, which are affecting people here in Houston as well as across the U.S. The origins of the opioid epidemic will be explored, along with rapidly growing new dangers such as fentanyl. There will be interdisciplinary discussions of advances in treatment modalities, both behavioral and pharmacological. Attending this symposium will inform clinicians at all levels about trends in and treatment of substance use disorders. This will help enhance the care that mental health professionals provide for their patients with psychiatric and substance use disorders.